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Provides completely updated insights into the mechanism of action of modern immunopotentiators and their potential use in future vaccines

Table of Contents

1. Vaccine Adjuvants' Mode of Action: Unraveling ‘‘the Immunologist's Dirty Little Secret” 2. The Role of Inflammasomes in Adjuvant-Driven Humoral and Cellular Immune Responses 3. Dendritic Cells as Targets of Vaccines and Adjuvants 4. Host-Derived Cytokines and Chemokines as Vaccine Adjuvants 5. Discovery of Immune Potentiators as Vaccine Adjuvants 6. Current Status of Toll-Like Receptor 4 Ligand Vaccine Adjuvants 7. Flagellins as Adjuvants of Vaccines 8. Toll-Like Receptor 7 and 8 Agonists for Vaccine Adjuvant Use 9. CpG Oligodeoxynucleotides as Adjuvants for Clinical Use 10. Advax Adjuvant: A Potent and Safe Immunopotentiator Composed of Delta Inulin 11. Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects 12. Polymeric Particles as Vaccine Delivery Systems 13. MF59: A Safe and Potent Adjuvant for Human Use 14. The Development of the Adjuvant System AS01: A Combination of Two Immunostimulants MPL and QS-21 in Liposomes 15. Development and Evaluation of AS04, a Novel and Improved Adjuvant System Containing 3-O-Desacyl-4'- Monophosphoryl Lipid A and Aluminum Salt 16. ISCOMATRIX Adjuvant in the Development of Prophylactic and Therapeutic Vaccines 17. Development and Evaluation of CAF01 18. Mineral Adjuvants 19. Toxin-Based Mucosal Adjuvants 20. Adjuvants for Skin Vaccination 21. Vaccination to Treat Noninfectious Diseases: Surveying the Opportunities 22. A Framework for Evaluating Nonclinical Safety of Novel Adjuvants and Adjuvanted Preventive Vaccines

About the Author

Dr. Virgil E.J.C. Schijns is special guest Professor in Cell Biology & Immunology group, Wageningen University, 6708 WD Wageningen, The Netherlands. Dr. Schijns received his Ph.D. degree at Utrecht University in 1990. Recent professional appointments are Chief Scientific Officer at ERC in Belgium and The Netherlands, (2011 to present); Chief Technology Officer, Vice-president at a small biotech spin-off from Utrecht University (2008 to 2011); Special professor immune Intervention, Wageningen University and Research center (2008 to present); Special Professor in Immunology and Virology at North Carolina State University (NCSU), Raleigh. Department of Population Health and Pathobiology (2002 to present) and Head of Department for Vaccine Technology and Immunology (VTI), AKZO NOBEL (1999 to 2008). Dr. Derek O’Hagan was the Global Head of Vaccine Chemistry and Formulation Research for Novartis Vaccines, based in Cambridge, MA until acquisition by GSK in March, 2015. He managed research teams (~50 total staff) in Cambridge and Siena, Italy. He originally qualified as a pharmacist in the UK, and is a former academic researcher who has worked on vaccine delivery in the industry since 1993. He was formerly a Lecturer in Drug Delivery at the Department of Pharmaceutical Sciences, University of Nottingham, UK, and received research funding from the World Health Organization, The Wellcome Trust and the Medical Research Council. He was recruited into the US in 1993, and moved to progress basic research into clinical evaluation, then subsequently worked on several vaccine delivery systems that were evaluated in the clinic, including novel adjuvants, nucleic acid vaccines and needle free vaccines. In the mid 1990’s, Dr. O’Hagan worked on the emulsion adjuvant MF59, which is now included in a licensed flu vaccine in more than 40 countries and is progressing towards licensure in the US. He has co-authored >140 original research publications, >60 book chapters and reviews and I am a named inventor on >60 filed patents. He was awarded the Conference Science medal of the Royal Pharmaceutical Society of Great Britain in 1997, and the Young Investigator Research Achievement Award of the Controlled Release Society in 1999. He was also named as the ‘most inventive scientist’ in Chiron in 2004 and was the lead author on the most cited paper in ‘Vaccine’ 2008-10. Dr. O’Hagan served on the Board of Scientific Advisors for the Controlled Release Society and is a Fellow of the American Association of Pharmaceutical Scientists.