The most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs
1. Introduction
2. Importance and applications of cell and tissue-based in vitro
models for drug permeability screening in early stages of drug
development
3. Immortalized cell-based in vitro culture models for drug
permeability studies
4. Primary isolated cell-based in vitro culture models for drug
permeability studies
5. Tissue-based in vitro culture models for drug permeability
studies
6. Correlation between cell and tissue-based in vitro models for
drug permeability screening with in vivo situation: Modeling and
functional extrapolation
BBruno Sarmento is Principal Investigator and Group Leader at
Institute for Research and Innovation in Health (i3S), University
of Porto (UP), and Invited Associate Professor at Instituto
Universitário de Ciências da Saúde (IUCS), Portugal.
His research is focused on the development of mucosal tissue
engineering models to validate functionalized nanomedicines and to
perform in vitro/in vivo correlation. He has also established
functionalized nanomedicines for mucosal drug delivery of drug with
poor mucosal bioavailability. He published more than 400 papers in
international journals, most in top journals (20000 Scopus
citations; H-index 73). He edited 5 books, participated in more
than 50 invited/selected talks in national and international
meetings and was awarded several distinctions. He has
supervised/co-supervised 15 Post-Docs, 50 PhD students and 40 MSc
students. He is editor of European Journal of Pharmaceutical
Sciences, and member of the Editorial Advisory Board of several
international journals, including the Journal of Controlled
Release, Expert Opinion on Drug Delivery and Pharmaceutics. Bruno
Sarmento was the first Chair of the Nanomedicine and Nanoscale
Delivery Focus Group of the Controlled Release Society (CRS) and is
now Director-at-Large of CRS and member of CRS College of Fellows.
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